Article

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells

2022-12-23

Abstract excerpt

Traditional cancer models rely on 2D cell cultures or 3D spheroids, which fail to recapitulate cell-extracellular matrix (ECM) interactions, a key element of tumor development. Existing hydrogel-based 3D alternatives lack mechanical support for cell growth and often suffer from low reproducibility. Here we report a novel strategy to make 3D models of breast cancer using a tissue-like, well-defined network environm...

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Literature Corpus work: 47fb35b4-9fd8-51e1-bc5f-d161866451fc
DOI: 10.1101/2022.12.22.521677

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