Article
TGFβ and matrix-regulated epithelial to mesenchymal transition
18 Feb 2014
Abstract excerpt
BACKGROUND: The progression of cancer through stages that guide a benign hyperplastic epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and microenvironmental factors that remodel the tissue architecture. The concept of epithelial-mesenchymal transition (EMT) has evolved to emphasize the importance of plastic changes in tissue architecture, and the cross-communication of...
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