Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer.

doi:10.18926/AMO/54826

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Article

Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer.

Acta medica Okayama - 1 Feb 2017

Yasuda Yukiko, Sakai Akiko, Ito Sachio, Sasai Kaori, Yamamoto Hiromasa, Matsubara Nagahide, Ouchida Mamoru, Katayama Hiroshi, Shimizu Kenji

Abstract excerpt

Human RAD17 acts as an activator of checkpoint signals in response to DNA damage. Here we evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of colorectal cancer (CRC) in relation to smoking and alcohol consumption habits in 212 CRC patients and 1,142 cancer-free controls in a case-control study conducted in Japan. The results showed that the hRAD17...

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PMID: 28238011
DOI: 10.18926/AMO/54826

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RAD17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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