Nucleotide excision repair related gene polymorphisms and genetic susceptibility, chemotherapeutic sensitivity and prognosis of gastric cancer.

doi:10.1016/j.mrfmmm.2014.04.008

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Article

Nucleotide excision repair related gene polymorphisms and genetic susceptibility, chemotherapeutic sensitivity and prognosis of gastric cancer.

Mutation research - 1 Jul 2014

Liu Jingwei, He Caiyun, Xing Chengzhong, Yuan Yuan

Abstract excerpt

Human genomic DNA is in a dynamic balance of damage and repair. Cells employ multiple and specific repair pathways, such as nucleotide excision repair (NER), as unrepaired DNA damage has deleterious consequences and could give rise to carcinogenesis. Gene polymorphisms play a crucial role in predicting the risk and prognosis of cancer. Polymorphisms of NER-related genes could alter the ability of NER to...

Topics

Animals
Antineoplastic Agents
DNA Damage
DNA Repair
Genetic Predisposition to Disease
Humans
Polymorphism, Genetic
Prognosis
Risk Factors
Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 24769428
DOI: 10.1016/j.mrfmmm.2014.04.008

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