Article
Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.
Oncology reports - 1 Nov 2007
Kanzaki Hirotaka, Ouchida Mamoru, Hanafusa Hiroko, Sakai Akiko, Yamamoto Hiromasa, Suzuki Hiromitsu, Yano Masaaki, Aoe Motoi, Imai Kazue, Date Hiroshi, Nakachi Kei, Shimizu Kenji
Abstract excerpt
The RAD18 gene, located on the human chromosome 3p24-p25, plays a crucial role in post-replication repair (PRR) in various organisms from yeast to humans. In the human RAD18 gene, one coding single nucleotide polymorphism (SNP) at codon 302, encoding either arginine (Arg, CGA) or glutamine (Gln, CAA), was reported. Although the molecular function of the RAD18 protein came to be elucidated, the association between...
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