Article
17β-estradiol prevents cardiac diastolic dysfunction by stimulating mitochondrial function: a preclinical study in a mouse model of a human hypertrophic cardiomyopathy mutation.
The Journal of steroid biochemistry and molecular biology - 1 Mar 2015
Chen Youzhou, Zhang Zhuoli, Hu Fenghuan, Yang Weixian, Yuan Jiansong, Cui Jingang, Hao Shujing, Hu Jie, Zhou Ying, Qiao Shubin
Abstract excerpt
OBJECTIVE: We investigated the effect of ovariectomy (OVX) and 17β-estradiol (E2) replacement on both mitochondrial and myocardial function in cTnT-Q92 transgenic mice generated by cardiac-restricted expression of a human hypertrophic cardiomyopathy (HCM) mutation. METHODS: The cTnT-Q92 mice were ovariectomized at twenty weeks of age and were treated with either placebo (OVX group) or E2 (OVX+E2 group) for twelve...
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