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Article

Histone H1 defect in escort cells triggers germline tumor in Drosophila ovary.

Developmental biology - 1 Apr 2017

Yang Zhihao, Sun Jin, Hu Yuzhao, Wang Fang, Wang Xia, Qiao Huan-Huan, Xu Jiang, Mao Decai, Ren Xingjie, Pan Li-Xia, Xu Rong-Gang, Xu Bo-Wen, Zhang Yifan, Li Haiyi, Miao Wei, Hu Yanhui, Chang Zhijie, Wang Dong, Li Haitao, Chang Zai, Liu Lu-Ping, Liu Qingfei, Ni Jian-Quan

Abstract excerpt

Drosophila ovary is recognized as one of the best model systems to study stem cell biology in vivo. We had previously identified an autonomous role of the histone H1 in germline stem cell (GSC) maintenance. Here, we found that histone H1 depletion in escort cells (ECs) resulted in an increase of spectrosome-containing cells (SCCs), an ovary tumor-like phenotype. Further analysis showed that the Dpp pathway is...

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PMID: 28232075
DOI: 10.1016/j.ydbio.2017.02.012

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GSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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