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Article

dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster.

PloS one - 21 May 2008

Yoon Jeongheon, Lee Kyu-Sun, Park Jung Sun, Yu Kweon, Paik Sang-Gi, Kang Yong-Kook

Abstract excerpt

Germline-stem cells (GSCs) produce gametes and are thus true "immortal stem cells". In Drosophila ovaries, GSCs divide asymmetrically to produce daughter GSCs and cystoblasts, and the latter differentiate into germline cysts. Here we show that the histone-lysine methyltransferase dSETDB1, located in pericentric heterochromatin, catalyzes H3-K9 trimethylation in GSCs and their immediate descendants. As germline...

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Source

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Identifiers

PMID: 18493619
DOI: 10.1371/journal.pone.0002234
PMCID: PMC2377335

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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