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Single-cell transcriptomic profiling of <i>bam</i> mutant tumor reveals germline heterogeneity and <i>gcrf1</i> as a modulator in <i>Drosophila</i> germ cells

2025-10-15

Abstract excerpt

The bam mutant ovary of Drosophila represents a classic tumor model caused by germline stem cell (GSC) differentiation defects. To date, its molecular and genetic features have rarely been characterized in detail at the single-cell resolution. Here, we performed single-cell RNA sequencing (scRNA-seq) to comprehensively delineate the transcriptomic landscape and identify distinct germline cell types in bam mutan...

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Literature Corpus work
a89a7ca4-6dfb-57d4-b3c1-7febdc5692be
DOI
10.1101/2025.10.14.682265
Open publication

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Single-cell transcriptomic profiling of <i>bam</i> mutant tumor reveals germline heterogeneity and <i>gcrf1</i> as a modulator in <i>Drosophila</i> germ cellsDOI 10.1101/2025.10.14.682265
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