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Article

The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients.

Drugs in R&D - 1 Jun 2017

Madsen Mads Juul, Bergmann Troels K, Brøsen Kim, Thiesson Helle Charlotte

Abstract excerpt

INTRODUCTION: Tacrolimus is a calcineurin inhibitor used as an immunosuppressant drug in solid organ transplantation, and is mainly metabolized by cytochrome P450 (CYP) 3A4 and CYP3A5. Studies have shown an association between the CYP3A5 genotype and tacrolimus dose-adjusted trough concentrations. Variants in the genes PPARA, POR and CYP3A4 have recently been shown to influence tacrolimus metabolism. Furthermore,...

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Source

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Identifiers

PMID: 28229376
DOI: 10.1007/s40268-017-0177-9
PMCID: PMC5427048

Genes

PPARA
POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients.PMID 28229376Read ↗

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