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Article

Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial.

Therapeutic drug monitoring - 1 Feb 2017

Billing Heiko, Höcker Britta, Fichtner Alexander, van Damme-Lombaerts Rita, Friman Styrbjorn, Jaray Jenö, Vondrak Karel, Sarvary Eniko, Dello Strologo Luca, Oellerich Michael, von Ahsen Nicolas, Tönshoff Burkhard

Abstract excerpt

BACKGROUND: The pharmacokinetics of tacrolimus (TAC) and mycophenolic acid (MPA) are highly variable. An impact of single-nucleotide polymorphisms (SNPs) of the genes coding for enzymes and transporters involved in the pharmacokinetics of TAC and/or MPA is intuitively conceivable. Accordingly, we sought to analyze the influence of different SNPs on TAC and MPA exposure in pediatric renal transplant recipients....

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Source

Identifiers

PMID: 28030534
DOI: 10.1097/FTD.0000000000000361

Genes

ABCB1
ABCC2
ABCG2

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Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial.PMID 28030534Read ↗

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