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Article

CYP3A5 and PPARA genetic variants are associated with low trough concentration to dose ratio of tacrolimus in kidney transplant recipients.

European journal of clinical pharmacology - 1 Jun 2021

Everton Janaína B F, Patrício Fernando J B, Faria Manuel S, Ferreira Teresa C A, Romao Elen A, Silva Gyl E B, Magalhães Marcelo

Abstract excerpt

PURPOSE: Genetic polymorphisms have been associated with variation in the metabolism of tacrolimus (TAC) in kidney transplant patients. This study is aimed at assessing the impact of allelic variants of CYP3A5 and PPARA genes on the pharmacokinetics (PK) of TAC in Brazilian kidney transplant recipients in the first-year post-transplant. METHODS: A total of 127 patients were included for genetic evaluation....

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PMID: 33398393
DOI: 10.1007/s00228-020-03076-8

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