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Article

Effects of CYP3A5 polymorphisms on tacrolimus pharmacokinetics in pediatric kidney transplantation: a systematic review and meta-analysis of observational studies.

World journal of pediatrics : WJP - 1 Oct 2017

Zong Yi-Ping, Wang Zi-Jie, Zhou Wan-Li, Zhou Wei-Min, Ma Tie-Liang, Huang Zheng-Kai, Zhao Chun-Chun, Xu Zhen, Tan Ruo-Yun, Gu Min

Abstract excerpt

BACKGROUND: CYP3A5 genetic polymorphisms have been reported to be strongly associated with the tacrolimus pharmacokinetics in adult kidney transplantation. However, there is no published meta-analysis in the influence of CYP3A5 variants on the requirements of the tacrolimus dose in pediatric renal-transplant recipients (RTRs). We wished to determine the effects of CYP3A5 polymorphisms on tacrolimus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28540692
DOI: 10.1007/s12519-017-0035-4

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