Article
Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.
Journal of Alzheimer's disease : JAD - 1 Jan 2020
Blujus Jenna Katherine, Korthauer Laura Elizabeth, Awe Elizabeth, Frahmand Marijam, Driscoll Ira
Abstract excerpt
BACKGROUND: It is critical to identify individuals at risk for Alzheimer's disease (AD) earlier in the disease time course, such as middle age and preferably well prior to the onset of clinical symptoms, when intervention efforts may be more successful. Genome-wide association and candidate gene studies have identified single nucleotide polymorphisms (SNPs) in APOE, CLU, CR1, PICALM, and SORL1 that confer...
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