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Article

Compliments of Factor H: What's in it for AMD?

Immunity - 21 Feb 2017

Mattapallil Mary J, Caspi Rachel R

Abstract excerpt

Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.

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Share to Complement Factor H
Share to CFH gene
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 28228273
DOI: 10.1016/j.immuni.2017.02.008
PMCID: PMC6123247

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Compliments of Factor H: What's in it for AMD?PMID 28228273Read ↗

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CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB PathwaySemantic proximity Read ↗

<i>CFH</i> loss in human RPE cells leads to inflammation and complement system dysregulation <i>via</i> the NF-κB pathwaySemantic proximity Read ↗

Age-related macular degeneration: Complement in action.Semantic proximity Read ↗

Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

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Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variantsSemantic proximity Read ↗

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