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Nanoparticle-Based Discrimination of Single-Nucleotide Polymorphism in Long DNA Sequences.

Bioconjugate chemistry - 19 Apr 2017

Sanromán-Iglesias María, Lawrie Charles H, Liz-Marzán Luis M, Grzelczak Marek

Abstract excerpt

Circulating DNA (ctDNA) and specifically the detection cancer-associated mutations in liquid biopsies promises to revolutionize cancer detection. The main difficulty however is that the length of typical ctDNA fragments (∼150 bases) can form secondary structures potentially obscuring the mutated fragment from detection. We show that an assay based on gold nanoparticles (65 nm) stabilized with DNA (Au@DNA) can...

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PMID: 28225258
DOI: 10.1021/acs.bioconjchem.7b00028

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