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Article

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

21 Feb 2017

Abstract excerpt

Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the functional response to combined pathway inhibition. PTEN (gene, mRNA, and protein) status was extensively characterized in a panel of cancer cell lines and combined MEK/mTOR inhibition displayed...

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PMID: 28220839
DOI: 10.1038/srep43013

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