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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

18 Aug 2023

Abstract excerpt

The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with several other signaling pathways, and dysregulation of signal transduction can predispose to cancer development....

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PMID: 37596643
DOI: 10.1186/s12943-023-01827-6

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