Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.

Nature chemical biology - 1 Feb 2021

Rathner Petr, Fahrner Marc, Cerofolini Linda, Grabmayr Herwig, Horvath Ferdinand, Krobath Heinrich, Gupta Agrim, Ravera Enrico, Fragai Marco, Bechmann Matthias, Renger Thomas, Luchinat Claudio, Romanin Christoph, Müller Norbert

Abstract excerpt

The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. On activation, STIM1 C terminus changes from an inactive, tight to an active, extended conformation. A coiled-coil clamp involving the CC1 and CC3 domains is essential in controlling STIM1 activation, with CC1 as the key entity. The nuclear magnetic resonance-derived solution structure of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelet Disorders
Share to Dyslexia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes, Abnormal

Share to Ichthyosis

Share to Migraine Disorders

Share to ORAI1 Protein

Share to Patch-Clamp Techniques

Share to Stromal Interaction Molecule 1

Source

Open in PubMed Open full text

Identifiers

PMID: 33106661
DOI: 10.1038/s41589-020-00672-8
PMCID: PMC7610458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.PMID 33106661Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

A single amino acid deletion in the ER Ca2+ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Semantic proximity Read ↗

Conserved and species-specific STIM autoinhibition revealed by AlphaFold3-guided dissectionSemantic proximity Read ↗

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.Semantic proximity Read ↗

Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change?Semantic proximity Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.