An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1.

doi:10.4049/jimmunol.1601894

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Article

An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2017

Zhao Quanju, Du Qinglin, Wei Fang, Xie Jianping, Ma Xiaojing

Abstract excerpt

IL-12 and IL-23 are important host defense factors produced by APCs against certain intracellular and extracellular pathogens. Their dysregulation has also been implicated in several autoimmune diseases. The nucleotide polymorphism in the promoter region of Il12b (rs41292470 consisting of the long or short allele) encoding the shared subunit of IL-12 and IL-23, p40, has been reported to associate with...

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PMID: 28219892
DOI: 10.4049/jimmunol.1601894

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