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Article

Analysis of IL12B gene variants in inflammatory bowel disease.

PloS one - 1 Jan 2012

Glas Jürgen, Seiderer Julia, Wagner Johanna, Olszak Torsten, Fries Christoph, Tillack Cornelia, Friedrich Matthias, Beigel Florian, Stallhofer Johannes, Steib Christian, Wetzke Martin, Göke Burkhard, Ochsenkühn Thomas, Diegelmann Julia, Czamara Darina, Brand Stephan

Abstract excerpt

BACKGROUND: IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD). However, the phenotypic effects and potential gene-gene interactions of IL12B variants are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed IL12B gene variants regarding association with Crohn's...

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Source

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Identifiers

PMID: 22479607
DOI: 10.1371/journal.pone.0034349
PMCID: PMC3316707

Genes

STAT4
HSF1
HSF2
MZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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