Article
A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production.
Arthritis research & therapy - 6 Sept 2017
Nakajima Toshiki, Yoshifuji Hajime, Shimizu Masakazu, Kitagori Koji, Murakami Kosaku, Nakashima Ran, Imura Yoshitaka, Tanaka Masao, Ohmura Koichiro, Matsuda Fumihiko, Terao Chikashi, Mimori Tsuneyo
Abstract excerpt
BACKGROUND: A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23. We investigated the expression of these cytokines in patients with TAK, stratifying them into those with or without the risk allele at the rs6871626 SNP....
Read the complete abstract on PubMed