Article
A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.
Genome medicine - 20 Feb 2017
Kumar Dilip, Puan Kia Joo, Andiappan Anand Kumar, Lee Bernett, Westerlaken Geertje H A, Haase Doreen, Melchiotti Rossella, Li Zhuang, Yusof Nurhashikin, Lum Josephine, Koh Geraldine, Foo Shihui, Yeong Joe, Alves Alexessander Couto, Pekkanen Juha, Sun Liang Dan, Irwanto Astrid, Fairfax Benjamin P, Naranbhai Vivek, Common John E A, Tang Mark, Chuang Chin Keh, Jarvelin Marjo-Riitta, Knight Julian C, Zhang Xuejun, Chew Fook Tim, Prabhakar Shyam, Jianjun Liu, Wang De Yun, Zolezzi Francesca, Poidinger Michael, Lane E Birgitte, Meyaard Linde, Rötzschke Olaf
Abstract excerpt
BACKGROUND: Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. We previously identified signal inhibitory receptor on leukocytes-1 (SIRL-1) as a powerful regulator of human innate immune cell function. While it is constitutively high expressed...
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