Article
A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study.
PloS one - 1 Jan 2018
Ben Hamda Cherif, Sangeda Raphael, Mwita Liberata, Meintjes Ayton, Nkya Siana, Panji Sumir, Mulder Nicola, Guizani-Tabbane Lamia, Benkahla Alia, Makani Julie, Ghedira Kais
Abstract excerpt
A chronic inflammatory state to a large extent explains sickle cell disease (SCD) pathophysiology. Nonetheless, the principal dysregulated factors affecting this major pathway and their mechanisms of action still have to be fully identified and elucidated. Integrating gene expression and genome-wide association study (GWAS) data analysis represents a novel approach to refining the identification of key mediators...
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