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Article

Demethylation of the FCER1G promoter leads to FcεRI overexpression on monocytes of patients with atopic dermatitis

10 Dec 2011

Abstract excerpt

BACKGROUND: Overexpression of the high-affinity receptor for immunoglobulin E on atopic monocytes and dendritic cells is known to contribute to the pathogenesis of atopic dermatitis (AD). However, it remains unclear what is the underlying mechanism of FcεRI deregulation. It has been speculated that epigenetic deregulation may play a role. METHODS: Global DNA methylation levels of monocytes from 10 AD patients and...

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PMID: 22150093
DOI: 10.1111/j.1398-9995.2011.02760.x

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