Article
Properties of STAT1 and IRF1 enhancers and the influence of SNPs.
BMC molecular biology - 9 Mar 2017
Abou El Hassan Mohamed, Huang Katherine, Eswara Manoja B K, Xu Zhaodong, Yu Tao, Aubry Arthur, Ni Zuyao, Livne-Bar Izzy, Sangwan Monika, Ahmad Mohamad, Bremner Rod
Abstract excerpt
BACKGROUND: STAT1 and IRF1 collaborate to induce interferon-γ (IFNγ) stimulated genes (ISGs), but the extent to which they act alone or together is unclear. The effect of single nucleotide polymorphisms (SNPs) on in vivo binding is also largely unknown. RESULTS: We show that IRF1 binds at proximal or distant ISG sites twice as often as STAT1, increasing to sixfold at the MHC class I locus. STAT1 almost always...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.