Article
[Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population].
Klinische Padiatrie - 1 Jan 2000
Zakel U A, Wudy S A, Heinzel-Gutenbrunner M, Görg T, Schäfer H, Gortner L, Blum W F, Hebebrand J, Hinney A
Abstract excerpt
BACKGROUND: The prevalence of childhood obesity is steadily increasing. Weight regulation and food intake are subject to complex regulatory mechanisms. The leptinergic-melanocortinergic system is known to be of major importance. AIM OF THE STUDY: Identification of mutations in the melanocortin 4 receptor gene (MC4R) and of phenotypic effects of detected mutations in German obese children and adolescents. Family...
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