Article
Investigation of BRAF mutation analysis with different technical platforms in metastatic melanoma.
Pathology, research and practice - 1 May 2017
Sener Ebru, Yildirim Pinar, Tan Ayca, Gokoz Ozay, Tezel Gaye Guler
Abstract excerpt
In metastatic melanoma, the detection of somatic mutations in the BRAF gene is crucial regarding patient selection for targeted therapy. Several screening methods have been developed to identify BRAF gene mutations. In this study, our objective was to evaluate the detection of the BRAF V600 mutations using two molecular methods, real-time polymerase chain (real-time PCR) assay and pyrosequencing, and...
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