Article
Heterogeneity and frequency of BRAF mutations in primary melanoma: Comparison between molecular methods and immunohistochemistry.
Oncotarget - 31 Jan 2017
Bruno William, Martinuzzi Claudia, Andreotti Virginia, Pastorino Lorenza, Spagnolo Francesco, Dalmasso Bruna, Cabiddu Francesco, Gualco Marina, Ballestrero Alberto, Bianchi-Scarrà Giovanna, Queirolo Paola, Grillo Federica, Mastracci Luca, Ghiorzo Paola
Abstract excerpt
Finding the best technique to identify BRAF mutations with a high sensitivity and specificity is mandatory for accurate patient selection for target therapy. BRAF mutation frequency ranges from 40 to 60% depending on melanoma clinical characteristics and detection technique used.Intertumoral heterogeneity could lead to misinterpretation of BRAF mutational status; this is especially important if testing is...
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