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Article

Lymph node metastases of melanoma: challenges for BRAF mutation detection.

Human pathology - 1 Jan 2015

Chen Guoli, Dudley Jonathan, Tseng Li-Hui, Smith Kirstin, Gurda Grzegorz T, Gocke Christopher D, Eshleman James R, Lin Ming-Tseh

Abstract excerpt

Detection of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations is required to predict response to BRAF or mitogen-activated protein kinase kinase 1 and 2 inhibitors in metastatic melanoma. Lymph node (LN) specimens carrying melanoma cells intermingled with abundant lymphocytes often contain low tumor cellularity. This study is aimed to examine challenges in the clinical detection of BRAF mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25456393
DOI: 10.1016/j.humpath.2014.09.014

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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