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Article

Revealing the Concealed Nature of Long-QT Type 3 Syndrome.

Circulation. Arrhythmia and electrophysiology - 1 Feb 2017

Greer-Short Amara, George Sharon A, Poelzing Steven, Weinberg Seth H

Abstract excerpt

BACKGROUND: Gain-of-function mutations in the voltage-gated sodium channel (Nav1.5) are associated with the long-QT-3 (LQT3) syndrome. Nav1.5 is densely expressed at the intercalated disk, and narrow intercellular separation can modulate cell-to-cell coupling via extracellular electric fields and depletion of local sodium ion nanodomains. Models predict that significantly decreasing intercellular cleft widths...

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Identifiers

PMID: 28213505
DOI: 10.1161/CIRCEP.116.004400
PMCID: PMC5319726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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