Article

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

2002-11-01

Abstract excerpt

Congenital long QT syndrome is a rare disease in which the electrocardiogram QT interval is prolonged due to dysfunctional ventricular repolarization.Variant 3 (LQT-3) is associated with mutations in SCN5A, the gene coding for the heart Na + channel α subunit.Arrhythmias in LQT-3 mutation carriers are more likely to occur at rest, when heart rate is slow.Several LQT-3 Na + channel mutations exert their deleterious...

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Literature Corpus work: b543895f-0887-5a7f-986b-09ce8872179d
DOI: 10.1172/jci0215928

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