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Article

Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.

Circulation. Arrhythmia and electrophysiology - 1 Aug 2015

Potet Franck, Beckermann Thomas M, Kunic Jennifer D, George Alfred L

Abstract excerpt

BACKGROUND: Mutations of the cardiac voltage-gated sodium channel (SCN5A gene encoding voltage-gated sodium channel [NaV1.5]) cause congenital long-QT syndrome type 3 (LQT3). Most NaV1.5 mutations associated with LQT3 promote a mode of sodium channel gating in which some channels fail to inactivate, contributing to increased late sodium current (INaL), which is directly responsible for delayed repolarization and...

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Source

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Identifiers

PMID: 26022185
DOI: 10.1161/CIRCEP.115.002760
PMCID: PMC4545406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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