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Article

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.

Cardiovascular research - 1 Apr 2012

Adeniran Ismail, El Harchi Aziza, Hancox Jules C, Zhang Henggui

Abstract excerpt

AIMS: One form of the short QT syndrome (SQT3) has been linked to the D172N gain-in-function mutation to Kir2.1, which preferentially increases outward current through channels responsible for inward rectifier K(+) current (I(K1)). This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias. METHODS AND RESULTS: The ten Tusscher et al. model for human...

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Action Potentials
Arrhythmias, Cardiac
CHO Cells
Cricetulus
Heart Ventricles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Cardiovascular

Patch-Clamp Techniques

Potassium Channels, Inwardly Rectifying

Source

Identifiers

PMID: 22308236
DOI: 10.1093/cvr/cvs082

Genes

KCNJ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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