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Article

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.

PLoS computational biology - 1 Jun 2017

Whittaker Dominic G, Ni Haibo, El Harchi Aziza, Hancox Jules C, Zhang Henggui

Abstract excerpt

Gain-of-function mutations in KCNJ2-encoded Kir2.1 channels underlie variant 3 (SQT3) of the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically-detailed human atria computer models, this study investigated the mechanistic link between SQT3 mutations and atrial arrhythmogenesis, and potential ion channel targets for treatment of SQT3. A contemporary model of the human atrial...

Topics

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Arrhythmias, Cardiac
Atrial Fibrillation
Heart Atria
Heart Conduction System
Models, Cardiovascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocardial Contraction

Potassium Channels, Inwardly Rectifying

Source

Open in PubMed Open full text

Identifiers

PMID: 28609477
DOI: 10.1371/journal.pcbi.1005593
PMCID: PMC5487071

Genes

KCNJ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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