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Article

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant.

Circulation - 22 Nov 2005

Liu Kai, Yang Tao, Viswanathan Prakash C, Roden Dan M

Abstract excerpt

BACKGROUND: The cardiac sodium channel (SCN5A) mutation L1825P has been identified in a patient with drug-induced torsade de pointes precipitated by the IKr blocker cisapride. Although L1825P generates late sodium current typical of SCN5A-linked long-QT syndrome (LQT3) in vitro, the patient reported had a normal QT interval before administration of the drug. To address this discrepancy, we tested the hypothesis...

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Identifiers

PMID: 16301357
DOI: 10.1161/CIRCULATIONAHA.105.564008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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