MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.

doi:10.18632/oncotarget.12164

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MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.

Oncotarget - 25 Oct 2016

Liu Bo, Yi Minxiao, Tang Yang, Liu Qingxu, Qiu Hong, Zou Yanmei, Peng Ping, Zhang Lu, Hu Chunping, Yuan Xianglin

Abstract excerpt

Matrix metalloproteinase-1 (MMP-1) has been implicated in several inflammatory and fibrotic diseases. We hypothesized that genetic variations in the MMP1 promoter region are associated with risk of radiation-induced lung injury (RILI). A cohort of 251 lung cancer patients was genotyped for five single nucleotide polymorphisms in the MMP1 promoter region. We found that rs1144393 AG/GG was strongly correlated with...

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PMID: 27659527
DOI: 10.18632/oncotarget.12164
PMCID: PMC5342544

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MMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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