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Article

Proteolysis regulates cardiomyocyte maturation and tissue integration.

Nature communications - 17 Feb 2017

Fukuda Ryuichi, Gunawan Felix, Beisaw Arica, Jimenez-Amilburu Vanesa, Maischein Hans-Martin, Kostin Sawa, Kawakami Koichi, Stainier Didier Y R

Abstract excerpt

Tissue integrity is critical for organ formation and function. During heart development, cardiomyocytes differentiate and integrate to form a coherent tissue that contracts synchronously. However, the molecular mechanisms regulating cardiac tissue integrity are poorly understood. Here we show that proteolysis, via the E3 ubiquitin ligase ASB2, regulates cardiomyocyte maturation and tissue integrity....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28211472
DOI: 10.1038/ncomms14495
PMCID: PMC5321751

Genes

TCF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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