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Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

27 May 2022

Abstract excerpt

Abstract The cardiac developmental network has been associated with myocardial regenerative potential. However, the embryonic signals triggered following injury have yet to be fully elucidated. Nkx2.5 is a key causative transcription factor associated with human congenital heart disease and one of the earliest markers of cardiac progenitors, thus it serves as a promising candidate. Here, we show that...

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PMID: 35624100
DOI: 10.1038/s41467-022-30468-4

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