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Cardiomyocyte-Specific <em>Bcl11b</em> Knockout Causes Left Ventricular Noncompaction by Dysregulating <em>Pou3f2</em> and <em>Titin</em>

2026-06-12

Abstract excerpt

Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by excessive trabeculation and deep intertrabecular recesses, yet its molecular mechanisms remain poorly understood. Here, we identify Bcl11b as a novel regulator of cardiomyocyte (CM) growth and ventricular wall maturation. CM-specific deletion of Bcl11b in mice recapitulates key LVNC features, including increased noncompact-ed-to-compacted r...

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Literature Corpus work
9488d9d8-2faf-5f9b-b3f0-dcd408f9eaf4
DOI
10.20944/preprints202606.1044.v1
Open publication

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Cardiomyocyte-Specific <em>Bcl11b</em> Knockout Causes Left Ventricular Noncompaction by Dysregulating <em>Pou3f2</em> and <em>Titin</em>DOI 10.20944/preprints202606.1044.v1
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