Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.

doi:10.1007/s00210-014-0972-6

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Article

Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2014

Hurt Carl M, Sorensen Matt W, Angelotti Timothy

Abstract excerpt

Various naturally occurring polymorphic forms of human G protein-coupled receptors (GPCRs) have been identified and linked to diverse pathological diseases, including receptors for vasopressin type 2 (nephrogenic diabetes insipidus) and gonadotropin releasing hormone (hypogonadotropic hypogonadism). In most cases, polymorphic amino acid mutations disrupt protein folding, altering receptor function as well as...

Topics

Cell Membrane
Genetic Variation
HEK293 Cells
Humans
Intracellular Fluid
Polymorphism, Genetic
Protein Binding
Protein Transport
Receptors, Adrenergic, alpha-2

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Identifiers

PMID: 24643471
DOI: 10.1007/s00210-014-0972-6
PMCID: PMC4035122

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