Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2014

Hurt Carl M, Sorensen Matt W, Angelotti Timothy

Abstract excerpt

Various naturally occurring polymorphic forms of human G protein-coupled receptors (GPCRs) have been identified and linked to diverse pathological diseases, including receptors for vasopressin type 2 (nephrogenic diabetes insipidus) and gonadotropin releasing hormone (hypogonadotropic hypogonadism). In most cases, polymorphic amino acid mutations disrupt protein folding, altering receptor function as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Genetic Variation
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intracellular Fluid

Share to Polymorphism, Genetic

Share to Protein Binding

Share to Protein Transport

Share to Receptors, Adrenergic, alpha-2

Source

Open in PubMed Open full text

Identifiers

PMID: 24643471
DOI: 10.1007/s00210-014-0972-6
PMCID: PMC4035122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.PMID 24643471Read ↗

G protein-coupled receptors disrupted in human genetic disease.Semantic proximity Read ↗

The G protein-coupled receptors: pharmacogenetics and disease.Semantic proximity Read ↗

G protein-coupled receptor pharmacogenetics.Semantic proximity Read ↗

G protein-coupled receptor mutations and human genetic disease.Semantic proximity Read ↗

A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α2C-Adrenergic Receptor Confers Impaired Coupling to Multiple EffectorsSemantic proximity Read ↗

Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets.Semantic proximity Read ↗

Pharmacogenetics of the G protein-coupled receptors.Semantic proximity Read ↗

Genetic variation of human adrenergic receptors: from molecular and functional properties to clinical and pharmacogenetic implications.Semantic proximity Read ↗

Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor FunctionSemantic proximity Read ↗

Misfolded G Protein-Coupled Receptors and Endocrine Disease. Molecular Mechanisms and Therapeutic Prospects.Semantic proximity Read ↗

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.Semantic proximity Read ↗

Genetic variations of α(2)-adrenergic receptors illuminate the diversity of receptor functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.