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Article

N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.

The Journal of biological chemistry - 23 May 2014

Hofherr Alexis, Wagner Claudius, Fedeles Sorin, Somlo Stefan, Köttgen Michael

Abstract excerpt

Glycosylation plays a critical role in the biogenesis and function of membrane proteins. Transient receptor potential channel TRPP2 is a nonselective cation channel that is mutated in autosomal dominant polycystic kidney disease. TRPP2 has been shown to be heavily N-glycosylated, but the glycosylation sites and the biological role of N-linked glycosylation have not been investigated. Here we show, using a...

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Identifiers

PMID: 24719335
DOI: 10.1074/jbc.M114.562264
PMCID: PMC4031537

Genes

PRKCSH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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