Article
FocusHeuristics - expression-data-driven network optimization and disease gene prediction.
Scientific reports - 16 Feb 2017
Ernst Mathias, Du Yang, Warsow Gregor, Hamed Mohamed, Endlich Nicole, Endlich Karlhans, Murua Escobar Hugo, Sklarz Lisa-Madeleine, Sender Sina, Junghanß Christian, Möller Steffen, Fuellen Georg, Struckmann Stephan
Abstract excerpt
To identify genes contributing to disease phenotypes remains a challenge for bioinformatics. Static knowledge on biological networks is often combined with the dynamics observed in gene expression levels over disease development, to find markers for diagnostics and therapy, and also putative disease-modulatory drug targets and drugs. The basis of current methods ranges from a focus on expression-levels (Limma) to...
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