Article
Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles.
BMC bioinformatics - 1 Jan 2013
Zhu Jie, Qin Yufang, Liu Taigang, Wang Jun, Zheng Xiaoqi
Abstract excerpt
BACKGROUND: Identification of gene-phenotype relationships is a fundamental challenge in human health clinic. Based on the observation that genes causing the same or similar phenotypes tend to correlate with each other in the protein-protein interaction network, a lot of network-based approaches were proposed based on different underlying models. A recent comparative study showed that diffusion-based methods...
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