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Article

Chapter 15: disease gene prioritization.

PLoS computational biology - 1 Apr 2013

Bromberg Yana

Abstract excerpt

Disease-causing aberrations in the normal function of a gene define that gene as a disease gene. Proving a causal link between a gene and a disease experimentally is expensive and time-consuming. Comprehensive prioritization of candidate genes prior to experimental testing drastically reduces the associated costs. Computational gene prioritization is based on various pieces of correlative evidence that associate...

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PMID: 23633938
DOI: 10.1371/journal.pcbi.1002902
PMCID: PMC3635969

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