Degree-adjusted algorithm for prioritisation of candidate disease genes from gene expression and protein interactome.

Abstract excerpt

Computational methods play an important role in the disease genes prioritisation by integrating many kinds of data sources such as gene expression, functional annotations and protein-protein interactions. However, the existing methods usually perform well in predicting highly linked genes, whereas they work quite poorly for loosely linked genes. Motivated by this observation, a degree-adjusted strategy is applied...

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