Article
Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014
Hu Lanjuan, Li Ning, Xu Chunming, Zhong Silin, Lin Xiuyun, Yang Jingjing, Zhou Tianqi, Yuliang Anzhi, Wu Ying, Chen Yun-Ru, Cao Xiaofeng, Zemach Assaf, Rustgi Sachin, von Wettstein Diter, Liu Bao
Abstract excerpt
Cytosine methylation at CG sites ((m)CG) plays critical roles in development, epigenetic inheritance, and genome stability in mammals and plants. In the dicot model plant Arabidopsis thaliana, methyltransferase 1 (MET1), a principal CG methylase, functions to maintain (m)CG during DNA replication, with its null mutation resulting in global hypomethylation and pleiotropic developmental defects. Null mutation of a...
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