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Article

A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.

The American journal of pathology - 1 Apr 2010

Mullan Ronan Hugh, McCormick Jennifer, Connolly Mary, Bresnihan Barry, Veale Douglas James, Fearon Ursula

Abstract excerpt

Acute phase apoprotein Serum Amyloid A (A-SAA), which is strongly expressed in rheumatoid arthritis synovial membrane (RA SM), induces angiogenesis, adhesion molecule expression, and matrix metalloproteinase production through the G-coupled receptor FPRL-1. Here we report alternative signaling through the high-density lipoprotein receptor scavenger receptor-class B type 1 (SR-B1). Quantitative...

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Identifiers

PMID: 20304957
DOI: 10.2353/ajpath.2010.090014
PMCID: PMC2843487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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