Article
SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma.
Oncogene - 12 Feb 2015
Lung H L, Man O Y, Yeung M C, Ko J M Y, Cheung A K L, Law E W L, Yu Z, Shuen W H, Tung E, Chan S H K, Bangarusamy D K, Cheng Y, Yang X, Kan R, Phoon Y, Chan K C, Chua D, Kwong D L, Lee A W M, Ji M F, Lung M L
Abstract excerpt
Nasopharyngeal carcinoma (NPC) is a cancer that occurs in high frequency in Southern China. A previous functional complementation approach and the subsequent cDNA microarray analysis have identified that serum amyloid A1 (SAA1) is an NPC candidate tumor suppressor gene. SAA1 belongs to a family of acute-phase proteins that are encoded by five polymorphic coding alleles. The SAA1 genotyping results showed that...
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