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Article

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

1 Jan 2017

Abstract excerpt

Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization. The multistep process of the metastastic colonization of tumours is influenced by the tissue and systemic microenvironment. From a screen of mutant mouse lines to identify microenvironmental modulators, David Adams,...

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PMID: 28052056
DOI: 10.1038/nature20792

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